Table 1.

Pharmacokinetic parameters of pinocembrin in rats after intragastrical administration of HCPT (50 mg/kg; n = 6, Mean ± S.D.) with or without treatment of verapamil.

Parameter	Control	Pre-treatment of verapamil
Tmax (h)	1.12 ± 0.14	0.89 ± 0.09
Cmax (ng/mL)	91.97 ± 11.30	125.30 ± 13.50*
t1/2 (h)	17.71 ± 3.60	23.00 ± 6.71*
AUC (0–t) (mg·h/L)	0.66 ± 0.10	1.14 ± 0.29*
MRT (h)	9.61 ± 0.55	11.45 ± 0.78*
CLz/F (L/h/kg)	63.85 ± 10.79	32.95 ± 6.17*

*p < 0.05 indicate significant differences from the control.