Table 3.

Cytotoxicity of L¹−L¹⁰ and DOX against certain axenic cancer cells and normal cell.

IC50 ± SEa( μM )
Compd.	Hela	HepG2	MCF-7	A549	HUVEC
L0	2.02 ± 0.02	2.56 ± 0.04	19.45 ± 0.39	5.02 ± 0.19	1.27 ± 0.03
L1	9.02 ± 0.25***	0.66 ± 0.02***	5.33 ± 0.16***	2.11 ± 0.06***	5.92 ± 0.17***
L2	59.52 ± 0.27***	28.78 ± 0.19***	14.48 ± 2.48*	>100	34.02 ± 1.57***
L3	54.38 ± 0.38***	1.63 ± 0.39***	2.65 ± 0.07***	95.48 ± 2.48***	16.65 ± 1.08*
L4	14.80 ± 0.22ns	45.99 ± 1.13ns	8.21 ± 0.65***	>100	>100
L5	>100	53.14 ± 1.95***	8.27 ± 0.21***	>100	>100
L6	>100	51.44 ± 2***	55.56 ± 2.56***	94.39 ± 2.56***	75.45 ± 12.44***
L7	43.53 ± 1.34***	24.01 ± 1.33***	11.82 ± 0.54**	83.60 ± 15.65***	66.77 ± 2.60***
L8	20.22 ± 0.89**	17.06 ± 0.07**	8.81 ± 0.54***	36.02 ± 2.18**	95.11 ± 0.97***
L9	52.46 ± 0.54***	44.94 ± 0.75***	6.66 ± 0.24***	>100	18.91 ± 1.72**
L10	>100	56.08 ± 6.11***	88.81 ± 3.46***	39.63 ± 1.74**	29.38 ± 2.35***
DOX	3.55 ± 0.17ns	1.20 ± 0.04ns	14 ± 1.03*	3.35 ± 0.69ns	4.40 ± 0.55***

ns: not significant, complexes compared with L⁰, respectively.

^aAverage IC₅₀ values from at least three independent experiments.

***p < .001.

**p < .01.

*p < .05.