Table 3.

Pharmacokinetic parameters for Taxotere^® and DTX-PMs in A549 xenograft tumor Balb/c nude mice following i.v. administration (10 mg DTX/kg).

Parameters	Unit	Whole blood		Plasma		Bone marrow		Tumor
		Taxotere®	DTX-PMs	Taxotere®	DTX-PMs	Taxotere®	DTX-PMs	Taxotere®	DTX-PMs
Kel	h−1	0.135	0.128	0.144	0.143	0.0838	0.0898	0.0251	0.0164
t1/2	h	5.2	5.4	4.8	4.9	8.3	7.7	28	42*
tmax	h					0.083	0.083	0.5	1.0*
Cmax	ng·g−1	3999	7230*	6226	10,011*	2942	3423	1763	1835
AUC0–t	h·ng·g−1	3293	4694	3605	5267	18,095	23,518	24,525	32,443
AUC0–inf	h·ng·g−1	3353	4775	3642	5306*	20,636	26,292	56,223	102,198*
AUMC0–t	h·h·ng·g−1	8822	10,866*	6299	7617	121,116	157,943	252,972	350,754
AUMC0–inf	h·h·ng·g−1	10,688	13,441*	7439	8834	212,418	255,420	2,277,576	6,270,774*
MRT	h	3.2	2.8	2.0	1.7	10	9.7	41	61*

^*p<.05.