Scheme 1.
(i) SOCl2, 60 °C, 30 min; (ii) Et3N, dry THF, rt, 90 min-6 h, 50–99%; (iii) NaOH, dry dioxane, 110 °C, 2–8 h, 57–100%; (iv) chloroalkylamine hydrochloride, K2CO3, dry DMF, 80 °C, 2–12 h, 17–69%.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.