Table 2.
Groups | Day 0 | Day 7 | Day 14 | Day 21 | Day 28 |
---|---|---|---|---|---|
Normal control | 77±2.23 | 80.33±1.80 | 81.66±3.41 | 80.66±2.50 | 76±1.92 |
STZ (110 mg/kg) + NA (45 mg/kg) | 414.33±3.52a* | 493.66±2.19a* | 520±1.15a* | 525.67±1.80a* | 546.65±3.40a* |
STZ + DCME 200 mg/kg | 428.63±2.13 | 393.33±1.75b* | 344.41±2.04b* | 278.34±1.19b* | 212.20±1.32b* |
STZ + DCME 400 mg/kg | 414.33±2.10 | 308.34±1.45b* | 221.33±1.46b* | 176.24±2.11b* | 104.66±3.40b* |
Diabetic + metformin 150 mg/kg | 425.31±3.33 | 254.22±2.10b* | 118.66±1.26b* | 84.42±1.14b* | 79.13±2.15b* |
Each values are expressed as mean±SEM (n=6), a*Diabetic control group versus normal control group (P<0.05), b*All treated group versus diabetic control group on corresponding day (P<0.05), *Values significantly differ from each other where P<0.05. SEM: Standard error of mean, DCME: Drymaria cordata methanolic extract, STZ: Streptozotocin, NA: Nicotinamide