Table 5.
Kinetic data of optimized terbinafine hydrochloride nanosponges and terbinafine hydrochloride nanosponges hydrogel
| Formulation | Zero order |
First order |
Higuchi diffusion |
Korsmeyer-Peppas |
Possible kinetics order and mechanism of the drug release | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| r | k | r | k | r | k | r | k | n | ||
| THCl nanosponges | 0.9962 | 0.2754 | 0.8949 | 0.0134 | 0.9913 | 7.3871 | 0.9999 | 0.0057 | 0.8609 | Zero-order kinetics, Case II transport |
| THCl nanosponges hydrogel | 0.9767 | 0.1575 | 0.9871 | 0.0056 | 0.9944 | 4.8418 | 0.9849 | 0.0148 | 0.6986 | Diffusion, Case II transport |
THCl: Terbinafine hydrochloride