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. 2020 Dec 11;69(3):413–423. doi: 10.2337/db19-0942

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© 2019 by the American Diabetes Association.

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Longitudinal IGF1 levels were stable in subjects with 1AAb⁺ at enrollment and decreased over time in those with multiple AAb⁺ at enrollment and subjects who progressed to type 1 diabetes. Subjects from longitudinal T1DBIT cohort. A: IGF1 does not show any correlation with time of longitudinal follow-up in 1AAb⁺ subjects, while a subset of those with multiple AAb⁺ and who developed type 1 diabetes show significantly decreasing IGF1 over time. B: IGF2 does not show any correlation with time of longitudinal follow-up in 1AAb⁺ subjects, while a subset of those with multiple AAb⁺ show significantly increasing IGF2 levels and those who developed type 1 diabetes show variable IGF2 levels over time. ●, subjects with significant slopes; ○, subjects with nonsignificant slopes in IGF over the course of the study. N.S., not significant. Kruskal-Wallis with Dunn multiple comparisons test: *P < 0.05, **P < 0.01.