Figure 4.

Subjects who progressed to type 1 diabetes showed reduction in IGF1 postdiagnosis. Subjects from longitudinal T1DBIT cohort. Grouped IGF trajectory data for subjects progressing to type 1 diabetes during the study reveal that IGF1 remains stable prediagnosis and decreases with time postdiagnosis in the same subjects (A) and that IGF2 levels were not significantly different in comparison of pre- and postdiagnosis trajectories (B). C: Random C-peptide levels are stable prediagnosis and decrease with time postdiagnosis. Data were normalized by baseline levels before or immediately after diagnosis. Best fit lines (solid) shown with 95% CI (dashed). Spearman correlation.