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. 2020 Dec 13;69(3):342–354. doi: 10.2337/db19-0281

Figure 6.

Figure 6

Little change in human islet PLIN2 and PLIN3 mRNA levels with respect to age or T2D. Relative PLIN1, 2, 3, 4, and 5 mRNA expression for islets in juvenile humans (age range 14 months–9 years) (A), adult humans (age range 39–68 years) (B), adult male C57BL6 mice (C), juvenile and adult humans (D), adults with T2D (age range 47–61 years) (E), age-matched adults without diabetes (ND) or with T2D (F), and adult humans and C57BL6 mice (G). There are no significant changes in PLIN mRNA expression between either healthy juvenile and adult islets (D) or adult healthy and T2D islets (F). The number of independent human and mouse islet samples analyzed is shown, with the adult ND number reduced for an age-matched comparison with T2D donor islets in F. Data presented relative to PLIN2 in A–C and E and relative to juveniles in D and to adult humans without diabetes in F and G. Error bars indicate SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs. PLIN1 in A–C and E or vs. adult humans in G; $P < 0.05, $$P < 0.01, $$$P < 0.001 vs. PLIN2; +++P < 0.001 vs. PLIN3 in A–C and E.