Table 4.
Top compound clusters enriched for IA-risk primary metabolites or complex lipids at infant age
| Compound cluster name | Cluster size | P values | Adjusted P values | Key compound | Altered metabolites | Increased | Decreased |
|---|---|---|---|---|---|---|---|
| GADA-first | |||||||
| Unsaturated TGs | 53 | 4E-14 | 1E-12 | TG62:1 | 5 | 0 | 5 |
| Unsaturated PCs | 40 | 5E-07 | 9E-06 | Plasmenyl-PC38:5 | 6 | 1 | 5 |
| Plasmalogens | 8 | 4E-05 | 0.0005 | Plasmenyl-PE36:6 | 2 | 0 | 2 |
| Sphingomyelins | 14 | 0.0005 | 0.005 | SM(d18:1/18:1) | 2 | 1 | 1 |
| PEs | 13 | 0.002 | 0.012 | PE38:2 | 3 | 0 | 3 |
| Unsaturated diglycerides | 7 | 0.002 | 0.012 | DG38:5 | 2 | 0 | 2 |
| IAA-first | |||||||
| Unsaturated TGs | 53 | 5E-14 | 2E-12 | TG52:4 | 11 | 0 | 11 |
| Sugar alcohols | 11 | 1E-05 | 0.0002 | Glycerol | 3 | 1 | 2 |
| Unsaturated phosphatidylcholines | 40 | 9E-05 | 0.0011 | PC32:1 | 8 | 3 | 5 |
| Butyrates | 4 | 0.0013 | 0.0091 | γ-aminobutyric acid | 3 | 2 | 1 |
| PEs | 13 | 0.0082 | 0.056 | LPE18:2 | 4 | 1 | 3 |