Figure 1.

Applications and attributes of cerebral organoids as a prion disease model.

Schematic showing the potential investigations that could be carried out using human cerebral organoids (upper) and direct comparison of the disease features recapitulated by organoids with other systems used for the investigation of human prion disease (lower). *: Only found in one study; †: limited astroglial population; ‡: spongiosis and gliosis were observed but could not be discerned from aging; §: if differentiated from neural stem cell cultures; ||: transgenic mice expressing human PrP. iPSC: Induced pluripotent stem cells; PrP: prion protein.