Table 2.
Effect of FSK on neuromitochondrial ETC complexes enzymatic assay in the brain homogenate of rats with autism induced by intracerebroventricular injection of PPA
| Treatment | Complex I (%control) | Complex II (nmol/mg protein) | Complex IV (%control) | Complex V (μmol/g tissue) |
|---|---|---|---|---|
| Normal | 100.0±0.0 | 7.34±0.61 | 100.0±0.0 | 607.5±14.52 |
| FSK only | 91.67±1.03 | 7.28±0.67 | 94.20±2.53 | 607.2±16.04 |
| PPA control | 25.83±3.71* | 1.34±0.37* | 32.73±2.34* | 208.5±15.83* |
| FSK 10mg/kg+PPA | 37.50±4.08# | 3.04±0.63# | 47.35±3.71# | 300.2±16.80# |
| FSK 20mg/kg +PPA | 52.50±8.01# | 4.76±0.59# | 66.20±3.92# | 392.2±22.29# |
| FSK30mg/kg +PPA | 74.00±7.48#@ | 6.15±0.42#@ | 81.61±2.59#@ | 485.5±20.74#@ |
Data expressed as the mean ± SD (n = 6). *P < 0.05, vs. normal and FSK only; #P < 0.05, vs. PPA control; @P < 0.05, vs. FSK10 mg/kg + PPA and FSK 20 mg/kg + PPA (one-way analysis of variance followed by Tukey’s post hoc test). FSK: Forkolin; PPA: propionic acid.