Table 3.
Effect of FSK on AChE and LDH levels in the brain homogenate of rats with autism induced by intracerebroventricular injection of PPA
| Treatment | LDH (IU/L) | AchE (μmol/mg protein) |
|---|---|---|
| Normal | 393.5±13.98 | 12.12±0.64 |
| FSK only | 394.2±13.32 | 12.20±0.50 |
| PPA control | 1114±26.69* | 39.31±0.82* |
| FSK10mg/kg+PPA | 876.8±22.73# | 33.84±0.63# |
| FSK20mg/kg+PPA | 704.8±15.00# | 27.46±0.87# |
| FSK30mg/kg+PPA | 460.3±18.01#@ | 20.59±0.98#@ |
Data expressed as the mean ± SD (n = 6). *P < 0.05, vs. normal and FSK only; #P < 0.05, vs. PPA control; @P < 0.05, vs. FSK10 mg/kg + PPA and FSK 20 mg/kg + PPA (one-way analysis of variance followed by Tukey’s post hoc test). AChE: Acetyl cholinesterase; FSK: forkolin; LDH: lactate dehydrogenase; PPA: propionic acid.