Table 4.
Effect of FSK on oxidative stress markers (MDA, GSH and nitrite) in the brain homogenate of rats with autism induced by intracerebroventricular injection of PPA
| Treatment | MDA (nmol/mg protein) | GSH (µmol/mg protein) | Nitrite (µmol/mg protein) |
|---|---|---|---|
| Normal | 1.20±0.30 | 11.31±0.56 | 1.27±0.14 |
| FSK only | 1.25±0.29 | 11.54±0.50 | 1.25±0.22 |
| PPA control | 11.73±0.90* | 1.96±0.51* | 9.25±0.31* |
| FSK10mg/kg+PPA | 7.1±0.75# | 3.04±0.22# | 5.87±0.14# |
| FSK20mg/kg+PPA | 4.24±0.41# | 4.07±0.24# | 3.54±0.20# |
| FSK30mg/kg+PPA | 2.69±0.38#@ | 5.34±0.24#@ | 2.18±0.19#@ |
Data expressed as the mean ± SD (n = 6). *P < 0.05, vs. normal and FSK only; #P < 0.05, vs. PPA control; @P < 0.05, vs. FSK10 mg/kg + PPA and FSK 20 mg/kg + PPA (one-way analysis of variance followed by Tukey’s post hoc test). FSK: Forkolin; GSH: reduced glutathione; MDA: malondialdehyde; PPA: propionic acid.