Table 5.
Effect of FSK on oxidative stress markers (SOD and catalase) in the brain homogenate of rats with autism induced by intracerebroventricular injection of PPA
| Treatment | SOD (%control) | Catalase (%control) |
|---|---|---|
| Normal | 100.0±0.0 | 100.0±0.0 |
| FSK only | 69.67±1.86 | 98.33±1.21 |
| PPA control | 19.33±5.31* | 35.17±1.60* |
| FSK10mg/kg+PPA | 39.67±2.50# | 56.67±1.21# |
| FSK20mg/kg+PPA | 55.67±4.03# | 67.50±1.87# |
| FSK30mg/kg+PPA | 83.50±4.59#@ | 82.50±2.07#@ |
Data expressed as the mean ± SD (n = 6). *P < 0.05, vs. normal and FSK only; #P < 0.05, vs. PPA control; @P < 0.05, vs. FSK10 mg/kg + PPA and FSK20 mg/kg + PPA (one-way analysis of variance followed by Tukey’s post hoc test). FSK: Forkolin; PPA: propionic acid; SOD: superoxide dismutase.