Table 6.
Effect of FSK on neuroinflammatory markers (IL-1β, TNF-α and IL-10) in the brain homogenate of rats with autism induced by intracerebroventricular injection of PPA
| Treatment | TNF-α (pg/mg protein) | IL-1β (pg/mg protein) | IL-10 (pg/mg protein) | IL-6 (pg/mg protein) |
|---|---|---|---|---|
| Normal | 32.02±2.09 | 66.53±3.64 | 51.31±2.52 | 44.76±3.36 |
| FSK only | 32.74±2.53 | 66.55±3.04 | 52.44±2.47 | 45.67±3.01 |
| PPA control | 371.3±17.67* | 517.9±15.41* | 32.13±1.72* | 250.7±7.15* |
| FSK10mg/kg+PPA | 274.2±12.87# | 408.0±7.46# | 41.11±1.66# | 209.3±7.11# |
| FSK20mg/kg+PPA | 226.9±19.45# | 348.4±10.96# | 48.03±2.00# | 160.2±3.78# |
| FSK30mg/kg+PPA | 168.9±13.22#@ | 245.6±8.70#@ | 52.96±1.56#@ | 122.8±6.04#@ |
Data are expressed as the mean ± SD (n = 6). *P < 0.05, vs. normal and FSK only; #P < 0.05, vs. PPA control; @P < 0.05, vs. FSK10 mg/kg + PPA and FSK20 mg/kg + PPA (one-way analysis of variance followed by Tukey’s post hoc test). FSK: Forkolin; IL: interleukin; PPA: propionic acid; TNF-α: tumor necrosis factor alpha.