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. 2019 Dec 10;15(6):1102–1110. doi: 10.4103/1673-5374.270418

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Copyright: © Neural Regeneration Research

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Amyotrophic lateral sclerosis, pathway ID# mmu05014.

During amyotrophic lateral sclerosis, miR-21a-5p was downregulated at the mitochondrial level, as were all three main neurofilaments (light, medium and heavy), compared with the negative control group. Yellow boxes represent proteins in the knockdown group, while green represents proteins that were not present in our data. MiR-21a-5p can be used as a biomarker to more comprehensively understand and identify the pathogenesis of amyotrophic lateral sclerosis.