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. 2020 Feb 14;11:104. doi: 10.3389/fimmu.2020.00104

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Copyright © 2020 Long, Xia, Xu, Liu, Fan, Bao, Zhao and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of functional subsets of TFR from UC patients and healthy controls (HC) according to Helios, TIGIT, and CD226. Peripheral blood from UC patients subsequently enrolled in this research, including active UC patients (n = 22) and stable remission UC patients (n = 22) and HC (n = 22) were collected and functional subsets of TFR cells were analyzed through staining for CD3, CD4, CXCR5, FoxP3, Helios, TIGIT, and CD226. (A) Representative dot plots for Helios and FoxP3 analysis. Numbers represent the percentages among CD3⁺CD4⁺CXCR5⁺ subsets. (B) Percentage of Helios⁺ TFR cells among CD3⁺CD4⁺CXCR5⁺FoxP3⁺ TFR cells (up) and absolute number of Helios⁺ TFR cells per liter in active or stable remission UC and HC (bottom). (C) Representative dot plots for analyzing expression of TIGIT (up) or CD226 (bottom) among TFR. Numbers represent percentages of TIGIT or CD226 positive cells in CD3⁺CD4⁺CXCR5⁺FoxP3⁺ TFR cells. (D) Percentages and absolute numbers of CD226⁺ TFR or TIGIT⁺ TFR subsets among TFR cells were compared among active UC patients, stable remission UC patients and HC. All symbols represent individual subjects and bars show the mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; ns, not significant.