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. 2020 Feb 14;11:104. doi: 10.3389/fimmu.2020.00104

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Copyright © 2020 Long, Xia, Xu, Liu, Fan, Bao, Zhao and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between TFR, TFH, TFH2 subsets, and clinical parameters in active UC patients. (A) Levels of CRP in active UC patients were measured, and correlation analysis with percentages of CD4⁺CXCR5⁺FoxP3⁺ TFR cells (n = 44), CD4⁺CXCR5⁺FoxP3⁻ TFH cells (n = 44), CXCR3⁻CCR6⁻ TFH2 subsets (n = 32) were performed. (B) The disease activity of UC was evaluated by Mayo Clinic Score, and correlations with TFR and TFH cells in active UC patients (n = 44), and with percentages of TFH2 cells in active UC patients (n = 32) were performed. The r-values were the Spearman's correlation coefficients, and p < 0.05 was linearly regressed to show relevant trends.