Table 1.
Anthropometric and fasting metabolic characteristics of the VALOBAB-C study population at screening
| Control | 3 g-PL | 5 g-PL | Healthy range/value | |
| (n=19) | (n=19) | (n=20) | ||
| Age (years) | 58±2 | 60±2 | 58±1 | – |
| Body weight (kg) | 78.5±2.5 | 75.3±1.9 | 75.6±1.1 | – |
| BMI (kg/m²) | 30.5±0.8 | 29.3±0.6 | 29.3±0.5 | 20–25* |
| Waist circumference (cm) | 96.5±2.4 | 97.0±1.5 | 97.9±1.4 | ≤80† |
| Hip circumference (cm) | 110.4±1.7 | 106.9±1.8 | 106.5±1.7 | – |
| Waist/hip circumference ratio | 0.87±0.02 | 0.91±0.01 | 0.92±0.01 | ≤0.85* |
| Systolic BP (mm Hg) | 132.1±2.9 | 129.2±3.1 | 133.7±2.6 | <130† |
| Diastolic BP (mm Hg) | 79.8±1.6 | 82.0±1.4 | 80.5±1.8 | <85† |
| Total C (mmol/L) | 6.0±0.2 | 5.7±0.2 | 5.8±0.2 | <5.2‡ |
| LDL-C (mmol/L) | 3.9±0.2 | 3.7±0.2 | 3.8±0.2 | ≤3.3‡ |
| HDL-C (mmol/L) | 1.3±0.0 | 1.4±0.0 | 1.3±0.0 | >1.3† |
| TAG (mmol/L) | 1.6±0.1 | 1.4±0.2 | 1.4±0.1 | <1.7† |
| Glucose (mmol/L) | 4.9±0.1 | 4.9±0.1 | 4.7±0.1 | <5.6† |
| CRP (mg/L) | 5.3±1.0 | 5.3±1.1 | 3.7±0.6 | <1–3§ |
| AST (IU/L) | 21.9±1.0 | 25.2±2.1 | 24.2±1.7 | <34¶ |
| ALT (IU/L) | 27.5±2.4 | 29.2±3.1 | 30.6±3.1 | <55¶ |
Data are presented as mean±SEM. Subjects were randomised therefore no statistical analysis was performed on subject characteristics at screening.
*According to WHO.66
†Based on the International Diabetes Federation metabolic syndrome worldwide definition.67
‡According to the National Cholesterol Education Program Adult Treatment Panel III.68
§Recommendations of the American Heart Association and Centers for Disease Control and Prevention established levels of cardiovascular risk by assigning CRP values as follows: low risk: <1.0 mg/L; average risk: 1.0–3.0 mg/L; high risk: >3.0 mg/L.31
¶According to reference ranges provided by the hospital laboratory in charge of the measurement of transaminases.
ALT, alanine amino transferase; AST, alanine aspartate transferase; BP, blood pressure; BMI, body mass index; C, cholesterol; CRP, C reactive protein; HDL, high-density lipoprotein; LDL, low-density lipoprotein; PL, polar lipids, TAG, triacylglycerol.