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. Author manuscript; available in PMC: 2020 Apr 3.
Published in final edited form as: ACS Appl Mater Interfaces. 2019 Mar 21;11(13):12298–12307. doi: 10.1021/acsami.9b00264

Figure 7. Viable macrophages do not augment antibiotic efficacy in a prevention paradigm.

Figure 7.

3D bioprinted scaffolds containing antibiotics only (Abx; daptomycin + rifampin), macrophages (MΦs) only, antibiotics + MΦs, or empty scaffolds were placed at the time of craniotomy, whereupon mice (n=8–12 per group) where challenged 1 day later with 108 CFU live S. aureus at the surgical site. Bacterial burdens were determined 7 days later. Results were analyzed by One-way ANOVA with Tukey’s multiple comparison test (*, p < 0.05; **, p < 0.01).