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. 2019 Jun 5;69(3):473–486. doi: 10.1136/gutjnl-2019-318263

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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The microbiome of patients with CD suffering from colon disease is different than that of patients with non-colonic disease. Patients with CD were divided according to disease location: colonic (n=24) and not colonic (n=65). (A) β-diversity using principal coordinate analysis of unweighted UniFrac distances (p=0.011) (B) Significantly abundant taxa in each of the groups by LEfSe analysis. (C and D) α-diversity using (C) Pielou’s evenness plot (p=0.02) and (D) Shannon’s diversity index (p=0.043). LEfSe, linear discriminant analysis effect size.