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. 2019 Jun 5;69(3):473–486. doi: 10.1136/gutjnl-2019-318263

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Microbiota of patients with CD differs when suffering from a flare. Patients were divided according to those who suffered a flare (eight samples) during gestation compared with those with stable disease (51 samples) and by IBD medication: 5-ASA oral and sup, immunosuppressants, biologicals and no medication (3, 14, 12 and 23 samples, respectively). (A) α-Diversity using Pielou’s evenness plot (p=0.025) and Shannon’s diversity index measurements (p=0.03) comparing flare and no flare samples. (B and C) Cladogram of significantly differentially abundant microbial taxa obtained using LEfSe divided by flare occurrence (B) or IBD medication (C). CD, Crohn’s disease.