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. 2019 Dec 18;79(3):400–407. doi: 10.1136/annrheumdis-2019-216055

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Association of IL1RN TTG haplotypes with radiographic severity. (A) Forest plot displaying association of IL-1RN haplotypes (TTG-0 vs TTG-1/2) with radiographic severity in symptomatic knee osteoarthritis (OA) patients in three cohorts. Study-specific estimates of ORs with 95% CIs between severity of knee OA defined as Kellgren-Lawrence (KL) 1/2 versus KL 3/4 for haplotype rs419598, rs315952 and rs9005 ‘T-T-G’ are shown for three independent and all three combined cohort. (B) Association of radiographic minimal medial joint space width (mJSW), age and IL1RN haplotypes in NYU, OAI and GOGO cohorts. Influence of IL-1 receptor antagonist (IL1RN) haplotypes on the age relationship to mJSW of knee OA. Carriers of either TTG-1 or TTG-2 compared with TTG-0 had narrower JSW (mm) at each age (years) studied. The joint space width (JSW) of each knee in patients with knee OA who do not (TTG-0) or do carry the IL1RN TTG haplotype is plotted relative to age, and the regression line is shown for JSW relative to age. The figure shows the linear regression line for each of the IL1RN risk haplotypes. OA patients 982 out of 1066 from three cohorts are represented. GOGO, Genetics of Generalized Osteoarthritis; FDR, false discovery rate; NYU, New York University; OAI, osteoarthritis initiative.