Table 1.

Demographic and radiographic characteristic features of symptomatic knee osteoarthritis patients from NYU, GOGO and OAI cohorts

Cohort	Age in years	Sex (% females)	BMI	Ethnicity (% Caucasians)	KL 3/4 (%)	mJSW in mm	Haplotype % frequencies
							TTG-0	CTA-1/2 (TTG-0)	TTG-1 (CTA-0)	TTG-2	CTA-1 (TTG-1)
NYU (n=372)	61.4 (±10.4)	62.7	26.41 (±3.52)	64	48.9	3.21 (±1.53)	22.3	8.0	46.0	15.3	10.5
GOGO (n=339)	67.0 (±8.2)	75.5	26.8 (±3.40)	100	29.8	3.35 (±1.4)	32.0	20.0	41.0	27.0	0
OAI (n=355)	61.6 (±9.0)	56.9	29.95 (±4.90)	80	57.7	3.54 (±1.65)	24.2	9.3	40.0	17.2	16.4
Combined (n=1066)	62.7 (±9.9)	64.4	27.36 (±4.15)	68.5	43.2	3.24 (±1.61)	26.3	12.0	42.2	19.5	9.0

Details are shown of the mean (±SD) age, BMI and mJSW in millimetres (mm), as well as percentage of females, Caucasians, radiographic KL score 3 or 4 distribution and IL1RN TTG haplotype frequency distribution. The TTG-0 groups also include CTA-1/2 haplotype group. Haplotypes TTG-0 or TTG-1 or TTG-2, respectively, represent carriers of 0 or 1 or 2 copies of IL1RN haplotype produced using 3 IL1RN single nucleotide polymorphisms (rs419598, rs315952 and rs9005).

BMI, body mass index; GOGO, Genetics of Generalized Osteoarthritis study, Duke University; KL, Kellgren-Lawrence; mJSW, minimal medial joint space width; NYU, New York University School of Medicine; OAI, osteoarthritis initiative.