Table 2.
Association of IL1RN haplotype (TTG) with radiographic mean minimal medial joint space width (mJSW) in three combined (NYU, GOGO and OAI) cohorts of symptomatic knee osteoarthritis patients
| Cohorts | TTG-0 | TTG-1 | TTG-2 | Beta (95% CI) | P value | FDR |
| NYU (n=372) | 3.43 (±1.44) (n=83) |
3.28 (±1.45) (n=209) |
2.60 (±1.70) (n=57) |
−0.39 (−0.64 to −0.13) |
0.0030 | 0.0046 |
| GOGO (n=339) | 3.67 (±1.31) (n=111) |
3.08 (±1.51) (n=138) |
3.35 (±1.38) (n=90) |
−0.18 (−0.38 to 0.02) |
0.0049 | 0.0950 |
| OAI (n=355) | 3.40 (±1.46) (n=86) |
3.20 (±1.63) (n=200) |
3.09 (±1.81) (n=61) |
−0.16 (−0.42 to 0.10) |
0.4787 | 0.2364 |
| All (n=1066) | 3.52 (±1.40) (n=280) |
3.20 (±1.53) (n=547) |
3.07 (±1.63) (n=208) |
−0.23 (−0.37 to −0.10) |
0.0023 | 0.0021 |
| All meta-analysis (n=1066) |
– | – | – | −0.23 (−0.37 to −0.10) |
0.0008 | 0.0021 |
mJSW data are presented in millimetres as mean (±SD) unless otherwise indicated; number of subjects in each group is represented in square brackets below each value. Haplotypes TTG-0 or TTG-1 or TTG-2, respectively, represent carriers of 0 or 1 or 2 copies of IL1RN haplotype produced using 3 IL1RN single nucleotide polymorphisms (rs419598, rs315952 and rs9005). Linear regression model (beta and 95% CI) was performed and p value was adjusted by FDR. The last row indicates the meta-analysis of all three cohorts by including cohort as a covariate.
FDR, false discovery rate; GOGO, Genetics of Generalized Osteoarthritis; NYU, New York University; OAI, osteoarthritis initiative.