Table 2.

Association of IL1RN haplotype (TTG) with radiographic mean minimal medial joint space width (mJSW) in three combined (NYU, GOGO and OAI) cohorts of symptomatic knee osteoarthritis patients

Cohorts	TTG-0	TTG-1	TTG-2	Beta (95% CI)	P value	FDR
NYU (n=372)	3.43 (±1.44) (n=83)	3.28 (±1.45) (n=209)	2.60 (±1.70) (n=57)	−0.39 (−0.64 to −0.13)	0.0030	0.0046
GOGO (n=339)	3.67 (±1.31) (n=111)	3.08 (±1.51) (n=138)	3.35 (±1.38) (n=90)	−0.18 (−0.38 to 0.02)	0.0049	0.0950
OAI (n=355)	3.40 (±1.46) (n=86)	3.20 (±1.63) (n=200)	3.09 (±1.81) (n=61)	−0.16 (−0.42 to 0.10)	0.4787	0.2364
All (n=1066)	3.52 (±1.40) (n=280)	3.20 (±1.53) (n=547)	3.07 (±1.63) (n=208)	−0.23 (−0.37 to −0.10)	0.0023	0.0021
All meta-analysis (n=1066)	–	–	–	−0.23 (−0.37 to −0.10)	0.0008	0.0021

mJSW data are presented in millimetres as mean (±SD) unless otherwise indicated; number of subjects in each group is represented in square brackets below each value. Haplotypes TTG-0 or TTG-1 or TTG-2, respectively, represent carriers of 0 or 1 or 2 copies of IL1RN haplotype produced using 3 IL1RN single nucleotide polymorphisms (rs419598, rs315952 and rs9005). Linear regression model (beta and 95% CI) was performed and p value was adjusted by FDR. The last row indicates the meta-analysis of all three cohorts by including cohort as a covariate.

FDR, false discovery rate; GOGO, Genetics of Generalized Osteoarthritis; NYU, New York University; OAI, osteoarthritis initiative.