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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: DNA Repair (Amst). 2020 Jan 16;87:102803. doi: 10.1016/j.dnarep.2020.102803

Figure 3. KEGG pathway profiling diagrams for individual agents.

Figure 3.

(A) Radial plot of frequency of different KEGG pathways in the DDR_MKOv4 library. Kyoto Encyclopedia of Genes and Genomes pathway enrichment ratio was analyzed from WebGestalt. All the input genes were shown in the top list with false discovery rate < 0.1. Values in radial plot indicate the enrichment ratio calculated using WebGestalt KEGG. (B-K) Radial plots of KEGG pathway enrichment for indicated agents. Please be aware that since these were negative screens, the higher enrichment ratio indicates that a given KEGG pathway is more likely to be depleted following treatment with these agents. HR, homologous recombination; MMR, mismatch repair; FA, Fanconi anemia; NHEJ, nonhomologous end-joining; BER, base excision repair; NER, nucleotide excision repair. ATMi, ATM inhibitor; ATRi, ATR inhibitor; CHK1i, CHK1 inhibitor; PARPi, PARP inhibitor; PKRi, PKR inhibitor.