. 2020 Feb 18;8:e8570. doi: 10.7717/peerj.8570

Table 5. Univariate and multivariate Cox proportional hazard analyses of the association of clinical characteristics with overall survival rates in patients with Klatskin tumors.

Variance	Univariate	P value	Multivariate	P value
	Hazard ratio (95% CI)		Hazard ratio (95% CI)
Age
<82 years	1		1
≥82 years	1.663(1.305–2.121)	<0.001	1.725(1.324–2.249)	<0.001
Race
White	1		1
Black	1.098(0.696–1.734)	0.687	1.735(1.063–2.831)	0.027
Other	0.997(0.718–1.384)	0.986	1.232(0.866–1.753)	0.246
Gender
Female	1		1
Male	1.024(0.817–1.284)	0.834	1.011(0.789–1.296)	0.929
Grade
Well differentiated	1		1
Moderate	0.504(0.208–1.222)	0.130	0.488(0.188–1.267)	0.141
Poor	0.875(0.386–1.984)	0.749	0.716(0.295–1.739)	0.461
Anaplastic	1.335(0.169–10.570)	0.784	3.911(0.370–41.325)	0.257
SEER historic stage
Localized	1		1
Regional	1.168(0.878–1.553)	0.287	1.878(1.144–3.082)	0.013
Distant	2.164(1.521–3.079)	<0.001	3.594(1.251–10.326)	0.018
AJCC stage
I	1		1
II	0.653(0.361–1.182)	0.159	1.874(0.730–4.809)	0.191
III	0.969(0.695–1.350)	0.851	0.751(0.390–1.448)	0.393
IV	2.020(1.401–2.914)	<0.001	0.723(0.248–2.106)	0.552
Stage T
T1	1		1
T2	0.646(0.418–0.998)	0.049	0.409(0.199–0.837)	0.014
T3	0.847(0.579–1.237)	0.390	0.783(0.466–1.316)	0.356
T4	1.124(0.767–1.647)	0.548	0.839(0.486–1.451)	0.530
StageN
N0	1		1
N1	1.301(0.957–1.768)	0.093	1.468(1.008–2.139)	0.046
Local treatment of the primary tumor
None	1		1
Surgery	0.393(0.246–0.630)	<0.001	0.555(0.316–0.977)	0.041
Alpha fetoprotein
Elevated	1		1
Normal	1.015(0.622–1.655)	0.953	1.077(0.643–1.805)	0.778
Fibrosis score
0-4	1		1
5-6	1.419(0.320–6.299)	0.645	0.682(0.141–3.302)	0.635

Notes.