Supplementary Table 1.
Clinical features of de novo stage IV triple-negative breast cancer patients by metastatic sites.
| Features | Bone metastases (%) | P- value | Lung metastases (%) | P- value | Liver metastases (%) | P- value | Brain metastases (%) | P- value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
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|
|
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| Yes | No | Yes | No | Yes | No | Yes | No | |||||
| Age (years) | 0.138 | 0.009 | 0.004 | 0.001 | ||||||||
| <65 | 623 (62.5) | 527 (59.1) | 540 (57.9) | 610 (63.8) | 416 (65.4) | 734 (58.6) | 188 (70.1) | 962 (59.4) | ||||
| ≥65 | 374 (37.5) | 364 (40.9) | 392 (42.1) | 346 (36.2) | 220 (34.6) | 518 (41.4) | 80 (29.9) | 658 (40.6) | ||||
|
| ||||||||||||
| Race | 0.261 | 0.099 | 0.644 | 0.726 | ||||||||
| White | 695 (69.7) | 590 (66.2) | 615 (66.0) | 670 (70.1) | 440 (69.2) | 845 (67.5) | 187 (69.8) | 1098 (67.8) | ||||
| Black | 242 (24.3) | 239 (26.8) | 248 (26.6) | 233 (24.4) | 159 (25.0) | 322 (25.7) | 63 (23.5) | 418 (25.8) | ||||
| Others | 60 (6.0) | 62 (7.0) | 69 (7.4) | 53 (5.5) | 37 (5.8) | 85 (6.8) | 18 (6.7) | 104 (6.4) | ||||
|
| ||||||||||||
| Grade | <0.001 | <0.001 | 0.349 | 0.167 | ||||||||
| G1/G2 | 186 (18.7) | 101 (11.3) | 113 (12.1) | 174 (18.2) | 97 (15.3) | 190 (15.2) | 36 (13.4) | 251 (15.5) | ||||
| G3/G4 | 644 (64.6) | 661 (74.2) | 678 (72.7) | 627 (65.6) | 450 (70.8) | 855 (68.3) | 180 (67.2) | 1125 (69.4) | ||||
| Unknown | 167 (16.8) | 129 (14.5) | 141 (15.1) | 155 (16.2) | 89 (14.0) | 207 (16.5) | 52 (19.4) | 244 (15.1) | ||||
|
| ||||||||||||
| Tumor size (cm) | <0.001 | <0.001 | 0.291 | 0.041 | ||||||||
| ≤2 | 155 (15.5) | 112 (12.6) | 113 (12.1) | 154 (16.1) | 90 (14.2) | 177 (14.1) | 49 (18.3) | 218 (13.5) | ||||
| 2–5 | 333 (33.4) | 292 (32.8) | 284 (30.5) | 341 (35.7) | 225 (35.4) | 400 (31.9) | 77 (28.7) | 548 (33.8) | ||||
| >5 | 310 (31.1) | 373 (41.9) | 393 (42.2) | 290 (30.3) | 228 (35.8) | 455 (36.3) | 89 (33.2) | 594 (36.7) | ||||
| Unknown | 199 (20.0) | 114 (12.8) | 142 (15.2) | 171 (17.9) | 93 (14.6) | 220 (17.6) | 53 (19.8) | 260 (16.0) | ||||
|
| ||||||||||||
| Node stage | 0.447 | 0.120 | 0.150 | 0.004 | ||||||||
| Node negative | 228 (22.9) | 214 (24.0) | 229 (24.6) | 213 (22.3) | 134 (21.1) | 308 (24.6) | 45 (16.8) | 397 (24.5) | ||||
| Node positive | 691 (69.3) | 620 (69.6) | 628 (67.4) | 683 (71.4) | 460 (72.3) | 851 (68.0) | 195 (72.8) | 1116 (68.9) | ||||
| Unknown | 78 (7.8) | 57 (6.4) | 75 (8.0) | 60 (6.3) | 42 (6.6) | 93 (7.4) | 28 (10.4) | 107 (6.6) | ||||
|
| ||||||||||||
| Surgery of the primary | <0.001 | 0.082 | 0.002 | <0.001 | ||||||||
| Yes | 305 (30.6) | 376 (42.2) | 318 (34.1) | 363 (38.0) | 199 (31.3) | 482 (38.5) | 54 (20.1) | 627 (38.7) | ||||
| No | 692 (69.4) | 515 (57.8) | 614 (65.9) | 593 (62.0) | 437 (68.7) | 770 (61.5) | 214 (79.9) | 993 (61.3) | ||||
|
| ||||||||||||
| Chemotherapy | 0.579 | 0.128 | 0.394 | 0.158 | ||||||||
| Yes | 722 (72.4) | 635 (71.3) | 655 (70.3) | 702 (73.4) | 465 (73.1) | 892 (71.2) | 183 (68.3) | 1174 (72.5) | ||||
| No/unknown | 275 (27.6) | 256 (28.7) | 277 (29.7) | 254 (26.6) | 171 (26.9) | 360 (28.8) | 85 (31.7) | 446 (27.5) | ||||
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| ||||||||||||
| Insurance | 0.430 | 0.115 | 0.466 | 0.213 | ||||||||
| Yes | 948 (95.1) | 835 (93.7) | 870 (93.3) | 913 (95.5) | 595 (93.6) | 1188 (94.9) | 247 (92.2) | 1536 (94.8) | ||||
| No | 40 (4.0) | 46 (5.2) | 50 (5.4) | 36 (3.8) | 33 (5.2) | 53 (4.2) | 17 (6.3) | 69 (4.3) | ||||
| Unknown | 9 (0.9) | 10 (1.1) | 12 (1.3) | 7 (0.7) | 8 (1.3) | 11 (0.9) | 4 (1.5) | 15 (0.9) | ||||
|
| ||||||||||||
| Marital status | 0.299 | 0.010 | 0.826 | 0.215 | ||||||||
| Married | 431 (43.2) | 373 (41.9) | 367 (39.4) | 437 (45.7) | 274 (43.1) | 530 (42.3) | 117 (43.7) | 687 (42.4) | ||||
| Unmarried | 526 (52.8) | 469 (52.6) | 513 (55.0) | 482 (50.4) | 330 (51.9) | 665 (53.1) | 144 (53.7) | 851 (52.5) | ||||
| Unknown | 40 (4.0) | 49 (5.5) | 52 (5.6) | 37 (3.9) | 32 (5.0) | 57 (4.6) | 7 (2.6) | 82 (5.1) | ||||