Supplementary Table 3.
Univariate and multivariate Cox regression analyses of prognostic factors for cancer-specific survival of patients with de novo stage IV triple-negative breast cancer.
| Features | Level | One site of distant metastases | Entire cohort | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||||
|
| |||||||||
| Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-P-value | Hazard ratio (95% CI) | P-value | ||
| Age (years) | <65 | Ref | Ref | Ref | Ref | ||||
| ≥65 | 1.230 (1.049–1.441) | 0.011 | 0.972 (0.820–1.151) | 0.739 | 1.216 (1.076–1.375) | 0.002 | 1.036 (0.911–1.178) | 0.590 | |
|
| |||||||||
| Race | White | Ref | – | Ref | – | ||||
| Black | 0.977 (0.819–1.166) | 0.799 | – | – | 1.038 (0.907–1.189) | 0.589 | – | – | |
| Others | 0.898 (0.654–1.233) | 0.505 | – | – | 0.877 (0.680–1.130) | 0.310 | – | – | |
|
| |||||||||
| Grade | G1/G2 | Ref | – | Ref | – | ||||
| G3/G4 | 1.007 (0.804–1.260) | 0.955 | – | – | 0.964 (0.814–1.142) | 0.674 | – | – | |
|
| |||||||||
| Tumor size (cm) | ≤2 | Ref | – | Ref | – | ||||
| 2–5 | 0.996 (0.770–1.287) | 0.973 | – | – | 0.962 (0.788–1.175) | 0.703 | – | – | |
| >5 | 1.068 (0.831–1.374) | 0.607 | – | – | 1.032 (0.849–1.255) | 0.750 | – | – | |
|
| |||||||||
| Node stage | Node negative | Ref | – | Ref | – | ||||
| Node positive | 1.103 (0.908–1.341) | 0.323 | – | – | 1.014 (0.872–1.179) | 0.857 | – | – | |
|
| |||||||||
| Surgery of the primary | No | Ref | Ref | Ref | Ref | ||||
| Yes | 0.502 (0.429–0.589) | <0.001 | 0.529 (0.450–0.621) | <0.001 | 0.502 (0.442–0.570) | <0.001 | 0.595 (0.522–0.679) | <0.001 | |
|
| |||||||||
| Chemo-therapy | No/unknown | Ref | Ref | Ref | Ref | ||||
| Yes | 0.399 (0.337–0.473) | <0.001 | 0.426 (0.354–0.512) | <0.001 | 0.383 (0.336–0.437) | <0.001 | 0.401 (0.350–0.461) | <0.001 | |
|
| |||||||||
| Insurance | Yes | Ref | Ref | Ref | Ref | ||||
| No | 2.237 (1.589–3.150) | <0.001 | 2.032 (1.427–2.892) | <0.001 | 1.861 (1.447–2.392) | <0.001 | 1.729 (1.337–2.237) | <0.001 | |
|
| |||||||||
| Marital status | Married | Ref | Ref | Ref | Ref | ||||
| Unmarried | 1.292 (1.101–1.516) | 0.002 | 1.185 (1.007–1.395) | 0.041 | 1.323 (1.170–1.496) | <0.001 | 1.183 (1.045–1.341) | 0.008 | |
|
| |||||||||
| Metastatic sites | Brian | Ref | Ref | – | – | ||||
| Bone | 0.580 (0.427–0.788) | <0.001 | 0.533 (0.391–0.726) | <0.001 | – | – | – | – | |
| Lung | 0.603 (0.443–0.821) | <0.001 | 0.544 (0.399–0.743) | <0.001 | – | – | – | – | |
| Liver | 0.676 (0.483–0.945) | 0.022 | 0.698 (0.498–0.978) | 0.037 | – | – | – | – | |
|
| |||||||||
| Number of metastatic sites | 1 | – | – | Ref | Ref | ||||
| >1 | – | – | – | – | 1.708 (1.512–1.929) | <0.001 | 1.584 (1.397–1.797) | <0.001 | |