Supplementary Table 4.

Multivariate Cox regression analysis of the impact of metastatic sites on overall survival when using metastasis of bone, lung, liver as the reference group.

Features	Level	Hazard ratio (95% CI)	P-value
Metastatic sites	Bone	Ref
	Lung	0.970 (0.829–1.134)	0.699
	Liver	1.299 (1.069–1.577)	0.008
	Brain	1.938 (1.472–2.551)	<0.001
Metastatic sites	Lung	Ref
	Bone	1.031 (0.882–1.206)	0.699
	Brain	1.998 (1.513–2.640)	<0.001
	Liver	1.339 (1.098–1.634)	0.004
Metastatic sites	Liver	Ref
	Lung	0.747 (0.612–0.911)	0.004
	Bone	0.770 (0.634–0.935)	0.008
	Brain	1.492 (1.105–2.014)	0.009