Figure 5.

Molecular weights (MWs) and octanol/water partition coefficients (logP) were visualized for all drug metabolite data sets [(A) drug-induced cholestasis, (B)] drug-induced cirrhosis, (C) drug-induced hepatitis, and (D): drug-induced steatosis]. Dotted lines were drawn where logP was 0 and molecular weight was 500. The majority of drug-induced liver injury (DILI)-positive drug metabolites had MWs less than 500. In particular, DILIpositive drug metabolites whose logP values were less than 0 had significantly decreased compared to DILI-positive parent drugs ( Figure 4 ).