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. 2015 Dec 9;2015(12):CD000407. doi: 10.1002/14651858.CD000407.pub4

Comparison 1. Oral corticosteroids (any dose) versus placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 Absolute change in per cent predicted FEV1 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
1.1.1 Up to 2 weeks 1 24 Mean Difference (IV, Fixed, 95% CI) 8.70 [2.32, 15.08]
1.1.2 Up to 12 weeks 1 24 Mean Difference (IV, Fixed, 95% CI) 8.10 [0.45, 15.75]
1.2 Absolute change in per cent predicted FVC 1   Mean Difference (IV, Fixed, 95% CI) Subtotals only
1.2.1 Up to 2 weeks 1 24 Mean Difference (IV, Fixed, 95% CI) 12.81 [4.73, 20.89]
1.2.2 Up to 12 weeks 1 24 Mean Difference (IV, Fixed, 95% CI) 6.70 [‐2.12, 15.52]
1.3 Growth retardation (at 4 years) 1   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.3.1 1 mg prednisone 1   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.3.2 2 mg prednisone 1   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.4 Height at age over 18 years (boys) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.4.1 1 mg prednisone 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.4.2 2 mg prednisone 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.5 Height at over 18 years (girls) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.5.1 1 mg prednisone 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.5.2 2 mg prednisone 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.6 Absolute change in weight (kg) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.6.1 Up to 12 weeks 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.7 Weight at over 18 years (boys) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.7.1 1 mg prednisone 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.7.2 2 mg prednisone 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.8 Weight at over 18 years (girls) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.8.1 1 mg prednisone 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.8.2 2 mg prednisone 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
1.9 Adverse events 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
1.9.1 Cataracts (1 mg prednisone) (up to 4 years) 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
1.9.2 Cateracts (2 mg prednisone) (up to 3 years) 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
1.9.3 Diabetes mellitus (1 mg prednisone) (up to 4 years) 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
1.9.4 Diabetes mellitus (2 mg prednisone) (up to 3 years) 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
1.9.5 Glucosoria (1 mg prednisone) (up to 4 years) 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
1.9.6 Glucosoria (2 mg prednisone) (up to 3 years) 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
1.9.7 Hyperglycemia (1 mg prednisone) (up to 4 years) 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
1.9.8 Hyperglycemia (2 mg prednisone) (up to 3 years) 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
1.10 Mortality 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
1.10.1 At 4 years 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected