Table 2. Dose dependent of biflavonoid on the levels of blood glucose, Insulin and Homeostatic model assessment of insulin resistant of control and experimental animals.
| Groups | Glucose (mg/dl) | Insulin ((IU/ml) | HOMA IR | |||
|---|---|---|---|---|---|---|
| Before Treatment | After Treatment | Before Treatment | After Treatment | Before Treatment | After Treatment | |
| Control | 85.13 ± 7.17 | 91.69 ± 6.19 | 18.66 ± 1.61 | 19.39 ± 1.72 | 3.91 ±0.35 | 4.40 ± 0.58 |
| Normal+ Biflavonoid (80mg/kg b.w) | 88.33 ± 7.17 | 93.22 ±8.80 | 16.95 ± 1.25 | 18.00 ± 1.42 | 3.70 ± 0.43 | 4.13 ± 0.41 |
| Diabetes Induced | 256.83 ± 12.61 | 306.85 ± 13.10b | 9.67 ± 11.16 | 10.12 ±0.89b | 6.29 ± 0.70 | 7.67 ± 0.82b |
| Diabetes + Biflavonoid (20mg/kg b.w) | 248.17 ±16.03 | 224.33 ± 12.77c | 11.16 ± 1.13 | 12.57 ±0.83c | 7.09 ± 0.93 | 6.96 ± 0.53c |
| Diabetes + Biflavonoid (40mg/kg b.w) | 232.83 ± 13.01 | 168.67 ± 14.56d | 12.13 ± 1.19 | 14.27 ± 1.45d | 7.42 ± 0.77 | 5.97 ± 1.01d |
| Diabetes + Biflavonoid (80mg/kg b.w) | 224.83 ± 8.91 | 130.39 ± 10.12e | 12.45 ± 1.16 | 16.86 ± 0.93e | 7.18 ±1.02 | 5.42 ± 0.40e |
| Diabetes + Metformin (500mg/kg b.w) | 87.33 ±7.30 | 125.83 ± 6.43f | 12.61 ± 0.86 | 17.30 ±1.17f | 7.00 ± 0.63 | 5.38 ± 0.50 |
Values are given as mean ± SD for six animals in each group.
Values are considered significantly different at P < 0.05 with post hoc LSD test *P < 0.05.
The symbols a, b c and d also represent the statistical significance at p < 0.05.
a Control vs Drug control rats(normal rats received biflavonoid alone).
b Control vs Diabetic rats.
c Diabetic control rats vs Diabetic rats treated with biflavonoid (20mg/kg).
d Diabetic control rats.vs Diabetic rats treated with biflavonoid (40mg/kg).
e Diabetic control rats.vs Diabetic rats treated with biflavonoid (800mg/kg).
f Diabetic rats treated with biflavonoid (80 mg/kg) vs Diabetic rats treated with Metformin (500mg/kg).