Table 3.

Ceramide ratios and MRI markers of structural brain injury.

	TBV		Hippocampal volume		WMHVa		Covert brain infarcts
	β ± SE	P‐value	β ± SE	P‐value	β ± SE	P‐value	OR (95% CI)	P‐value
Ceramide 24:0/16:0	0.03 ± 0.05	0.44	−0.001 ± 0.001	0.46	−0.05 ± 0.02	0.02	0.98 (0.82–1.17)	0.79
Ceramide 22:0/16:0	0.07 ± 0.05	0.17	−0.0004 ± 0.001	0.74	−0.06 ± 0.02	0.003	1.04 (0.87–1.24)	0.68

Model adjusted for age, age squared, sex, time from blood draw to MRI brain, systolic blood pressure, use of antihypertensive medication, prevalent cardiovascular disease, TC:HDL ratio, use of lipid‐lowering therapies, and serum TG.

Abbreviations: SDU, Standard deviation units; SE, Standard error; TBV, total brain volume; WMHV, White matter hyperintensity volume.

^aNatural log transformed.