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. 2020 Feb 14;8:1. doi: 10.3389/fchem.2020.00001

Figure 6.

Figure 6

(A) Schematic illustration of ICG-liposome-based PTT and dual blocking PD-1 and Tim-3 combination therapy to inhibit distal tumor growth. MC-38-bearing mice were then treated with PTT, anti-PD-1 + anti-TIM-3, PTT + anti-PD-1, and PTT + anti-PD-1 + anti-TIM-3. Tumor growth (B) and Kaplan–Meier survival curves (E) of tumor-bearing mice are shown. Pooled data of day 13 (C) and day 28 (D) from the experiments shown in (B). aP and aT represent anti-PD-1 and anti-TIM-3 therapy, respectively. n = 5 in each group. Data are presented as means ± SEM. Statistical significance in (B–D) was calculated by Student's t-test. Statistical significance for survival analysis in (E) was calculated by the log-rank test. ***P < 0.001, **P < 0.01, *P < 0.05.