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. 2003 Jul 21;2003(3):CD000412. doi: 10.1002/14651858.CD000412.pub2

Bringer 1985.

Methods Randomised trial. 
 Method of randomisation not described. 
 Cross‐over study, pre‐ and post‐ crossover data combined.
9 patients were randomised
Participants Clomiphene citrate resistant infertile women. 
 Patients had high androgen levels and high LH. Presence of polycystic ovaries at laparoscopy. 
 Nothing was mentioned about the age and BMI of these women and there was no information on infertility work‐up. Mean LH (+/‐ SEM) was 12,1 (2,9) respectively. 
 The study was performed at the Hospital Lapeyronie in Montpellier, France. Timing and duration of study was not stated.
Interventions Pulsatile GnRH VERSUS HMG for ovulation induction.
IV pulsatile GnRH was started on cycle day 2 or 5 after spontaneous or induced menses, using a portable pump at 8‐20 mcg/pulse every 90 to 128 minutes. 
 HMG was administered intramuscularly at cycle days 2 and 5 (75 or 150 IU). Based on ultrasound and E2 evaluation, doses were individualised. HMG was stopped and hCG (5,000 IU) injected when at least 1 but not more than 3 follicles >18 mm had developed.
Outcomes Pregnancy rate (per woman) 
 Ovulation rate (per cycle) 
 OHSS (per cycle)
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear