Remorgida 1991.

Methods	Randomised trial. Method of randomisation not described. Crossover study, only the pre‐crossover data are included. 8 patients were randomised
Participants	Clomiphene citrate resistant women with oligomenorrhoea and infertility for at least 3 years. All patients had at least 3 prior attempts of pulsatile GnRH therapy before, without ovulation as outcome. Mean age (+/‐ SEM) was 27.6 yeas (1,15). Patients had an infertility work‐up consisting of laparoscopy, hysterosalpingography, and semenanalysis. Mean BMI (+/‐ SEM) was 24.4 kg/m2 (1.09) and mean LH/FSH ratio (+/‐ SEM) was 3,5 (0,16) respectively. The study was performed at the University of Genoa, Italy. Timing and duration of study not stated.
Interventions	Pulsatile GnRH and FSH VERSUS FSH only for ovulation induction. IV pulsatile GnRH was started on (progestin‐induced) cycle day 2, using a portable pump at 20 mcg/pulse every 59 minutes. On cycle days 5,7, and 9 patients received two ampules of pure FSH (75IU/ampule). Patients treated with FSH alone took FSH on cycle days 3,5, and 7 (two ampules 75IU/ampule). In both groups, based on ultrasound and E2 evaluation, the FSH therapy was individualized (0‐4 ampules). FSH and/or GnRH‐pump was stopped and hCG (5,000 IU) injected when at least 1 but not more than 3 follicles >18 mm had developped.
Outcomes	Pregnancy rate (per woman) Ovulation rate (per woman) Multifollicular growth (per woman)
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear