Scheele 1993.

Methods	Randomised trial. Method of randomisation not described. Cross‐over study, pre‐ and post‐crossover data combined. 12 patients were randomised
Participants	Women with oligo‐ or amenorrhoea and raised LH/FSH ratio. Not selected for clomiphene citrate resistance. Mean age (+/‐ SEM) was 30 years (4). Infertility work‐up was not specified. Mean BMI (+/‐ SEM) was 26.3 kg/m2 (7.2) and mean LH/FSH ratio (+/‐ SEM) was 1,7 (1,2) respectively. The study was performed at the Free University of Amsterdam, The Netherlands. Timing and duration of trial not stated.
Interventions	Pulsatile GnRH following GnRHa pretreatment VERSUS pulsatile GnRH only for ovulation induction. IV pulsatile GnRH was started on (progestin‐induced) cycle day 2, using a portable pump at 10 mcg/pulse ever 90 minutes. Discontinuation of treatment when: no ovulation after 5 weeks, menses or positive pregnancy test. GnRHa (Buselerin) was self‐administered intra‐nasally (4 times daily, 300 mcg) during 3 weeks. The day after discontinuation, pulsatile LHRH was started.
Outcomes	Ongoing pregnancy (per woman) Clinical pregnancy (per woman) Ovulation rate (per cycle) Miscarriage rate (per pregnancy) Multifollicular growth (per cycle)
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear