| Methods |
Randomised trial. Randomisation with sealed envelopes (oral communication)
30 patients were randomised. 2 patients dropped out before treatment. Data analysis of 28 patients. |
| Participants |
Women with oligo‐or amenorrhoea and LH level>6.5 IU/L and/or LH‐FSH ratio >1.5.
women not treated with clomiphene citrate previously
Median age was 26 in the GnRH group and 27 in the clomiphene citrate group. Only information about semen analysis was available in the study.
The study was performed at the Catharina Hospital, Eindhoven, The Netherlands.
Timing and duration of study was not stated. |
| Interventions |
Pulsatile GnRH following GnRH pretreatment with GnRHa VERSUS clomiphene citrate
Patients in the GnRHa group received for at least 3 weeks, 400 mcg nafarelin/day. Immediately after discontinuing GnRHa, a iv pulsatile GnRH was started at 10 mcg/pulse at pulse interals of 90 minutes. The clomiphene citrate group received 50 mg climiphene citrate on cycle days 3‐7 after spontaneous or induced menses.
GnRH was increased to a maximum of 20 mcg and clomiphene citrate to a maximum of 150 mg after anovulation. |
| Outcomes |
Pregnancy rate (per woman)
Ovulation rate (per cycle)
Multifollicular growth (per cycle)
Pregnancy tests were performed 16 days after ovulation by determination of B‐hCG in the urine and serum.
Ovulation was assumed by disappearance of the dominant follicle on vaginal ultrasound and a subsequent increase in serum P (>10 nmol/l). |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
High risk |
C ‐ Inadequate |
