Paraskeva 2000.

Methods	Randomized, active control trial
Participants	Patients (N = 16), aged 18‐58 years, with acute, steroid resistant Ulcerative colitis, which had previously responded and tolerated IV cyclosporin (4 mg/kg/day). Pateints were in maintenance therapy on tapered steroids and 5‐ASA
Interventions	Group A: n = 8, oral azathioprine (2.5 mg/kg/day) for 6 months Group B: n = 8, oral cyclosporin (4 mg/kg/day) for 6 months All patients were on tapering steroids and were on maintenance therapy with 5‐ASA Follow‐up after medication discontinuation for another 12 months
Outcomes	Primary outcome: Proportion of patients still in remission Secondary outcome: Safety data
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described in abstract
Allocation concealment (selection bias)	Unclear risk	Not described in abstract
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not described in abstract
Incomplete outcome data (attrition bias) All outcomes	Low risk	Missing/withdrawn data was accounted for with explanation. Intention to treat analysis used
Selective reporting (reporting bias)	Low risk	No protocol was available, all outcomes were reported
Other bias	Low risk	The study appears not to have any other forms of bias