Table 4.
Summary of TEAD family expression in malignancies. When known cofactors, as well as target genes, are reported.
| Cancer Type | TEAD gene | Expresion in Cancer | Target genes | Cofactors | Reference |
|---|---|---|---|---|---|
| Pancreatic cancer | TEAD1 | Up-regulated | mesothelin | Hucl et al., 2007 | |
| Prostate cancer | TEAD1 | Up-regulated | Knight et al., 2008) | ||
| Kaposi sarcoma | TEAD1 | Up-regulated | www.ebi.ac.uk/gxa | ||
| Basal-like breast cancers | TEAD4 | Up-regulated | Han et al., 2008; | ||
| Breast cancer | TEAD1 | down-regulated | Landin Malt et al., 2012 | ||
| Breast cancer | TEADs | Up-regulated | CTGF/CYR61/Myc | TAZ/YAP/AP1 | Zanconato et al. 2015 Lamar, J.M. 2012 |
| Fallopian tube carcinoma | TEAD4 | Up-regulated | Nowee et al., 2007 | ||
| Germ cell tumors | TEAD4 | Up-regulated | Skotheim et al., 2006 | ||
| Renal cancer | TEAD1 | down-regulated | Landin Malt et al., 2012 | ||
| Bladder cancer | TEAD1 | down-regulated | Landin Malt et al., 2012 | ||
| Endometrial cancer | TEAD1 | Up-regulated | Livin/BIRC1 | ?/YAP1 | Landin Malt et al., 2012 and 2013 |
| Ovarian cancer | TEADs | Up-regulated | YAP1 | Xia et al., 2014 | |
| Cutaneous Melanoma | TEAD1/4 | Up-regulated | YAP1/AP1 | Yuan et al., 2015/ Verfaillie et al., 2015 | |
| Liver cancer | TEAD1 | Up-regulated | AXL receptor kinase | YAP1 | Xu, M.Z. et al. 2011, Liu-Chittenden, Y et al. 2012 |
| Colon cancer | TEAD4 | Up-regulated | vimentin | YAP1 | Liu, Y. et al 2015 |
| Gastric cancer | TEAD1/4 | Up-regulated | VGLL4/YAP | Li et al., 2015 |