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. Author manuscript; available in PMC: 2020 Feb 21.
Published in final edited form as: Int J Obes (Lond). 2013 May 21;38(2):170–176. doi: 10.1038/ijo.2013.82

Figure 5.

Figure 5.

FGF21 upregulates brown fat-like thermogenic program in WAs. (a) WAs expressed high level of β-klotho (N = 5). (b) FGF21 treatment increased UCP1 expression dose dependently in WAs (N = 3). *P<0.01. (c) UCP1 was undetectable in untreated WA but became strongly expressed following FGF21 treatment (detectable 3/3 samples at 100 nM and 1/3 at 10 nM). (d) Basal OCR and respiratory uncoupling were higher in FGF21-treated adipocytes (N = 6). FGF21-treated adipocytes displayed (e) significantly greater norepinephrine-induced thermogenesis (N = 5), (f) fatty acid oxidation (N = 4). *P<0.01, **P<0.001. Arrow indicates norepinephrine injection.