Table 5.

Comparison of overall asthma control test score, spirometry, and physiological evaluation of subjects enrolled in the trial for the treatment of severe asthma by itraconazole and prednisolone

	Before trial		After one month		After 4 months
	Itraconazole	Prednisolone	Itraconazole	Prednisolone	Itraconazole
FVC (L)	1.6±0.92	1.8±0.7	2.3±0.87†‡	1.69±0.68	3.1±1.84‡
FVC percent	55.2±22.23	60.3±16.65	71.8±18.8†‡	57.7±21.8	79±39‡
FEV1 (L)	1.3±0.73	1.14±0.45	1.9±0.8†‡	1.1±0.2	2.4±1.51‡
FEV1 percent	50.16±22.7	48.2±15.4	71.5±21.8†‡	47.8±17.9	82.5±30.4‡
FEV1/FVC	72.8±12.61	72.1±15.39	79.1±12.7†‡	64.7±10.3	89.5±0.7‡
FEV1/VC	70.82±22.7	78±20.3	76.6±14.6†	70±21.1	96.5±9.1‡
FEF25-75 (L/S)	1.21±0.8*	0.86±0.43	2.02±1.1†‡	0.9±0.59	2.6±1.95‡
FEF25-75 percent	36.8±21.83*	25.3±16.2	58.1±26.1†‡	33.2±28.4¥	75.5±40.3‡
FEF25-75/FVC	0.71±0.29*	0.51±0.3	0.83±0.28†	0.57±0.26¥	0.9±0.19
FENO (PPM)	36.8±29.2	28.6±25.2	34.6±26.5	35.2±22.1	29±17.9
Lukocyte count	9129±3378.8	9900±3093	8900±2524	9000±1414	8397±1596
Eosinophile count	446±699.9	703±676.1	682±773	180±28	1016±203
Eosinophile percent	5.7±7.11	10±12.5	8.1±9.4	2±0.4	5.1±7.5
Neutrophile count	5252±2993	6266±1824	5126±1754	4550±1343	3810±2354
Neutrophile percent	55.7±13.64*	63.7±3.3	57.6±11.2	50±7.07	45±24
Serum IgE	482±670	323±88	424±442	332±882	571±116

FVC= forced vital capacity; FEV1= Forced expiratory volume in one second; VC= vital capacity; FEF25-75= Forced expiratory flow between 25-75% of vital capacity; FENO= Fraction of expiratory nitric oxide; IgE= immunoglobulin E

*= Significant difference before and after the trial in the itraconazole group (paired t-test)

†=Significant difference between case and control group after a one-month treatment with itraconazole

‡= Significant difference after the trial in the Itraconazole group (paired t-test)

¥= Significant difference after the trial in the placebo group (paired t-test)