Table 3. The top 30 functional enrichment terms enriched for the hub genes identified in this study.
| Category | ID | Term | Count | P-value | FDR |
|---|---|---|---|---|---|
| BP | GO:0006364 | rRNA processing | 21 | 1.23E-09 | 1.05E-09 |
| BP | GO:0022613 | Ribonucleoprotein complex biogenesis | 26 | 3.75E-09 | 3.21E-09 |
| BP | GO:0016072 | rRNA metabolic process | 21 | 3.75E-09 | 3.21E-09 |
| BP | GO:0042254 | Ribosome biogenesis | 22 | 3.75E-09 | 3.21E-09 |
| BP | GO:0034470 | ncRNA processing | 24 | 3.75E-09 | 3.21E-09 |
| BP | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 13 | 6.54E-09 | 5.59E-09 |
| BP | GO:0006613 | Cotranslational protein targeting to membrane | 13 | 1.13E-08 | 9.64E-09 |
| BP | GO:0045047 | Protein targeting to ER | 13 | 1.67E-08 | 1.43E-08 |
| BP | GO:0072599 | Establishment of protein localization to endoplasmic reticulum | 13 | 2.47E-08 | 2.11E-08 |
| BP | GO:0000956 | Nuclear-transcribed mRNA catabolic process | 15 | 1.51E-06 | 1.29E-06 |
| BP | GO:0090150 | Establishment of protein localization to membrane | 16 | 7.43E-06 | 6.35E-06 |
| BP | GO:0006401 | RNA catabolic process | 18 | 1.77E-05 | 1.51E-05 |
| BP | GO:0050852 | T cell receptor signaling pathway | 12 | 5.27E-05 | 4.51E-05 |
| BP | GO:0042110 | T cell activation | 19 | 8.12E-05 | 6.95E-05 |
| CC | GO:0022626 | Cytosolic ribosome | 12 | 7.34E-07 | 5.92E-07 |
| CC | GO:0044391 | Ribosomal subunit | 13 | 1.18E-05 | 9.49E-06 |
| CC | GO:0005840 | Ribosome | 14 | 1.90E-05 | 1.53E-05 |
| CC | GO:0005925 | Focal adhesion | 17 | 5.83E-05 | 4.69E-05 |
| CC | GO:0005924 | Cell-substrate adherens junction | 17 | 5.83E-05 | 4.69E-05 |
| CC | GO:0030055 | Cell-substrate junction | 17 | 5.83E-05 | 4.69E-05 |
| CC | GO:0044445 | Cytosolic part | 13 | 6.70E-05 | 5.40E-05 |
| CC | GO:0022625 | Cytosolic large ribosomal subunit | 7 | 1.36E-04 | 1.10E-04 |
| CC | GO:0001772 | Immunological synapse | 5 | 8.29E-04 | 6.68E-04 |
| CC | GO:0015934 | Large ribosomal subunit | 8 | 9.12E-04 | 7.35E-04 |
| CC | GO:0008180 | COP9 signalosome | 5 | 9.12E-04 | 7.35E-04 |
| CC | GO:0042101 | T cell receptor complex | 4 | 1.12E-03 | 9.06E-04 |
| CC | GO:0022627 | Cytosolic small ribosomal subunit | 5 | 2.67E-03 | 2.15E-03 |
| CC | GO:1904813 | Ficolin-1-rich granule lumen | 7 | 7.77E-03 | 6.26E-03 |
| MF | GO:0003735 | Structural constituent of ribosome | 11 | 6.27E-04 | 5.28E-04 |
| KEGG | hsa03010 | Ribosome | 12 | 3.09E-04 | 3.08E-04 |
BP: biological process; CC: cellular component; MF: molecular function; KEGG: Kyoto Encyclopedia of Genes and Genomes; FDR: false discovery rate.