Table 1. Comparison between practice effects group and non-practice effects group.
| Study | Total Duration (months) |
Duration Between baseline and 2nd measurement (months) |
N (%) with Practice Effects | Baseline ADAS-cog11 | Baseline Age, y | Education, y | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Treatment | Placebo | p | N/ Total, (%) |
PE** | Non-PE | p | PE** | Non-PE | p | PE** | Non-PE | p | |||
| ADNI AD |
24 | 6 | NA | 60/176 (34.1) |
NA | 60/176 (34.1) |
20.0 | 17.9 | 0.0439 | 76.5 | 74.5 | 0.0991 | 14.7 | 14.8 | 0.92 |
| DHA | 18 | 6 | 76/219 (34.7) |
45/151 (29.8) |
0.32 | 121/370 (32.7) |
23.5 | 23.7 | 0.8051 | 75.5 | 76.0 | 0.6102 | 14.5 | 14.2 | 0.3810 |
| ES | 15 | 2 | 34/78 (43.6) |
13/38 (34.2) |
0.33 | 47/116 (40.5) |
24.2 | 23.6 | 0.7029 | 75.0 | 75.4 | 0.7118 | 12.4 | 12.2 | 0.7419 |
| HC | 18 | 6 | 99/230 (43.0) |
59/160 (36.9) |
0.22 | 158/390 (40.5) |
23.8 | 21.4 | 0.0074 | 76.5 | 76.3 | 0.7426 | 14.0 | 13.8 | 0.5173 |
| LL | 18 | 6 | 74/193 (38.3) |
78/188 (41.5) |
0.53 | 152/381 (39.9) |
25.5 | 23.1 | 0.0235 | 74.6 | 73.8 | 0.4183 | 14.0 | 14.4 | 0.2177 |
| NS | 14 | 3 | 83/209 (39.7) |
43/103 (41.8) |
0.73 | 126/312 (40.4) |
22.9 | 23.9 | 0.3715 | 74.5 | 73.5 | 0.2501 | 14.2 | 13.9 | 0.3756 |
| PR | 16 | 28 weeks | 32/69 (46.4) |
31/69 (44.9) |
0.86 | 63/138 (45.7) |
24.1 | 19.9 | 0.0121 | 70.6 | 73.8 | 0.0134 | 14.2 | 13.9 | 0.6091 |
| SL | 24 | 1 | 103/236 (43.6) |
31/76 (40.8) |
0.66 | 134/312 (43.0) |
38.3 | 38.9 | 0.5907 | 72.8 | 72.2 | 0.5360 | 12.6 | 12.4 | 0.7548 |
| VN | 26 | 6 | 26/113 (23.0) |
35/114 (30.7) |
0.19 | 61/227 (26.9) |
31.2 | 27.4 | 0.0036 | 75.4 | 75.7 | 0.8011 | 13.3 | 13.9 | 0.2012 |
| ADNI MCI |
24 | 6 | NA | 175/386 (45.3) |
NA | 175/386 (45.3) |
12.5 | 10.8 | 0.0003 | 73.9 | 75.6 | 0.0241 | 15.5 | 15.8 | 0.45 |
| MCI | 36 | 3 | 258/457 (56.5) |
145/241 (60.2) |
0.35 | 403/698 (57.7) |
11.9 | 10.2 | <.0001 | 72.0 | 73.2 | 0.0240 | 14.7 | 14.7 | 0.996 |
Baseline ADAS-cog scores for participants with practice effects were significantly higher than for those without in 6 trials but were similar in the other 4 trials. Age and the years of education were mostly similar.
PE: practice effects, Non-PE: Non-practice effects