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. 2020 Feb 21;15(2):e0224775. doi: 10.1371/journal.pone.0224775

Fig 6. Intra-tumoral gene expression and survival outcomes in human sarcomas from the cancer genome atlas.

Fig 6

The Cancer Genome Atlas (TCGA) was queried for gene expression data with immunoregulatory function from human sarcoma patients with non-metastatic disease. Patients were categorized into high and low expression by quartiles, and survival differences were analyzed between low expression (quartile 1) and high expression (quartile 4). Significant survival differences were identified between high and low gene expression for (A) CD3e, (B) CD8a, (C) IFN-γ (E) PRF1 (perforin), (F) CD122/ interleukin 2 (and interleukin 15) receptor subunit beta, (G) IL-6, and (H) IL-6R. Notably, and somewhat paradoxically, greater intra-tumoral expression of IL-6 and IL-6R were associated with superior survival in human sarcomas. Sarcoma patients with higher intra-tumoral GZMB (granzyme B) expression (D) had longer survival, but this difference was not statistically significant (HR 0.65, 95% CI 0.37–1.13, P = 0.13).