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Cytokine profiles to LPS following BCG and β-glucan priming as compared to medium control conditions (A) In neonates, IL-6 (n = 15) cytokine production significantly increased in BCG-primed monocytes. (B) In adults, IL-6 (n = 30) production after LPS re-stimulation increased significantly after BCG priming. β-glucan priming of monocytes led to a significant increase of all cytokine levels (IL-6, IL-10 and TNF) in both neonates and adults. *P < .05; **P < .01; ***P < .001.
