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| Compound | Mean Papp (10−6 cm s−1) | Rank |
|---|---|---|
| A to B | P app | |
| Nadolol | 0.08 | Low |
| Metoprolol | 16.40 | High |
| II-10c | <0.01 | Low |
Binning criteria: low permeability: Papp ≤ 0.5 (×10−6 cm s−1); moderate permeability: 0.5 < Papp < 2.5 (×10−6 cm s−1); high permeability: Papp ≥ 2.5 (×10−6 cm s−1).
